Progress With Genetic Cardiomyopathies
نویسندگان
چکیده
منابع مشابه
Genetic spectrum of cardiomyopathies with neuromuscular phenotype.
Neuromuscular disorders are known to be associated with cardiac disease but often the cardiovascular symptoms can be difficult to unravel due to low physical activity in this patient group and thereby low strain on the heart. On the other hand, cardiomyopathy or cardiac arrhythmogenic disease may be the first sign of an underlying neuromuscular disorder. Indeed, of the more than 40 genes that h...
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Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economic burden of heart failure (HF) remain unacceptably high. There is increasing evidence that the risk and course of HF depend on genetic predisposition; however, the genetic contribution to HF is heterogeneous and complex. At one end of the spectrum are the familial monogenic HF syndromes in which ...
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This review focuses on the genetic cardiomyopathies: principally dilated cardiomyopathy, with salient features of hypertrophic cardiomyopathy and arrhythmogenic right ventricular dysplasia/cardiomyopathy, regarding genetic etiology, genetic testing, and genetic counseling. Enormous progress has recently been made in identifying genetic causes for each cardiomyopathy, and key phenotype and genot...
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Major advances in the field of molecular genetics have expanded our ability to identify genetic substrates underlying the pathogenesis of various disorders that follow Mendelian inheritance patterns. Included among these disorders are the potentially lethal and heritable channelopathies and cardiomyopathies for which the underlying genetic basis has been identified and is now better understood....
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2009
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.108.817346